Ethanol → Ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate

HRID 1087174Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1087174
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20])[C:13]([OH:15])=[O:14].[CH2:22](O)[CH3:23]>Cl>[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[S:9][C:10]1[CH:11]=[C:12]([CH:16]=[CH:17][C:18]=1[N+:19]([O-:21])=[O:20])[C:13]([O:15][CH2:22][CH3:23])=[O:14]

Komponenten

4

Edukt 2

HCID 702EthanolHCID 100867683-(2,4-Difluorophenylthio)-4-nitrobenzoic acid

Produkt 1

HCID 10359815Ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

A solution of 3-(2,4-difluorophenylthio)-4-nitrobenzoic acid (1.2 g) in 20% hydrogen chloride in ethanol (3 ml) was refluxed for 2 hours. The mixture was concentrated. The residue was dissolved in ethyl acetate and washed with an aqueous solution of sodium bicarbonate and water successively. The extract was evaporated and the residual oil was crystallized from a mixture of hexane and ethanol to give crystals of ethyl 3-(2,4-difluorophenylthio)-4-nitrobenzoate (1.1 g).

Aufarbeitung

  1. concentrationThe mixture was concentrated
  2. dissolutionThe residue was dissolved in ethyl acetate
  3. washwashed with an aqueous solution of sodium bicarbonate and water successively
  4. customThe extract was evaporated
  5. customthe residual oil was crystallized from a mixture of hexane and ethanol

Quellen und Nachweise

ORD-Eintrag
ord-21550f48741d48fda2cb1c5a0abf243d
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05034417

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