Ethyl Acetate → 2-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile

HRID 1087191Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1087191
[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7](Cl)=[CH:6][C:3]=1[C:4]#[N:5].[F:14][C:15]1[CH:21]=[C:20]([F:22])[CH:19]=[CH:18][C:16]=1[S-:17].[K+].C(OCC)(=O)C>C1(C)C=CC=CC=1>[Cl:1][C:2]1[CH:9]=[C:8]([N+:10]([O-:12])=[O:11])[C:7]([S:17][C:16]2[CH:18]=[CH:19][C:20]([F:22])=[CH:21][C:15]=2[F:14])=[CH:6][C:3]=1[C:4]#[N:5]

Komponenten

5

Edukt 3

HCID 8857Ethyl AcetateHCID 198177342,5-Dichloro-4-nitrobenzonitrileHCID 23700122Potassium 2,4-difluorothiophenoxide

Produkt 1

HCID 198177012-Chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrileAusbeute 45,2 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of 2,5-dichloro-4-nitrobenzonitrile (2.5 g) and potassium 2,4-difluorothiophenoxide (2.54 g) in toluene was stirred overnight. Ethyl acetate was added and the resulting mixture was washed with water, dried and evaporated. The residue was filtered and washed with toluene to give pale brown crystals of 2-chloro-5-(2,4-difluorophenylthio)-4-nitrobenzonitrile (1.7 g).

Aufarbeitung

  1. washthe resulting mixture was washed with water
  2. customdried
  3. customevaporated
  4. filtrationThe residue was filtered
  5. washwashed with toluene

Quellen und Nachweise

ORD-Eintrag
ord-6d73aab75ba54c018334c300b3d59aa7
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05034417

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