HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Dichloromethane → 2-(4-Methylpiperazino)-3-phenylpropionic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Dichloromethane | HCID 6344 | — |
| Edukt | 1-Methylpiperazine | HCID 53167 | — |
| Edukt | Ethyl 2-bromo-3-phenylpropanoate | HCID 4737529 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | 2-(4-Methylpiperazino)-3-phenylpropionic acid ethyl ester | HCID 15058496 | 14,3% |
Reaktionsschritte
EThyl 2-bromo-3-phenylpropionate (1.95 g) was treated with 3.05 g N-methylpiperazine as described in Example 95 to afford 0.30 g pure product after chromatography (9:1 CH2Cl2 :MeOH). NMR (300 MHz, CDCl3) delta 1.10 (d, J=7 Hz, 3H), 2.26 (s, 3H), 3.37 (m, 1H), 4.00 (m, 2H).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US05034376 |
| Quelldatensatz | uspto-grants-1991_07 |
| ORD ID | ord-199580f190c84b378ea700c2e98da722 |
| Quellennotiz | uspto-grants-1991_07 |