Amino-6-ethoxybenzothiazole, 2- → N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

HRID 1087472

Reaktionsgleichung

Reaktionsgleichung von HRID 1087472
[NH2:1][C:2]1[S:3][C:4]2[CH:10]=[C:9]([O:11][CH2:12][CH3:13])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][O:15][CH2:16][C:17](Cl)=[O:18]>N1C=CC=CC=1>[CH2:12]([O:11][C:9]1[CH:8]=[CH:7][C:5]2[N:6]=[C:2]([NH:1][C:17](=[O:18])[CH2:16][O:15][CH3:14])[S:3][C:4]=2[CH:10]=1)[CH3:13]

Komponenten

4

Edukt 2

HCID 7192Amino-6-ethoxybenzothiazole, 2-HCID 96623Methoxyacetyl chloride

Produkt 1

HCID 652526N-(6-ethoxy-1,3-benzothiazol-2-yl)-2-methoxyacetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

2-Amino-6-ethoxybenzothiazole (5.8 g) is dissolved in pyridine (100 ml) and thereto is added dropwise methoxyacetyl chloride (3.0 ml) at room temperature. After the mixture is stirred at room temperature for 2 hours, the solvent is distilled off. The resulting solids are washed with water, then with diethyl ether, dried and recrystallized from ethanol to give the title compound (5.1 g) having the following physical properties.

Aufarbeitung

  1. distillationthe solvent is distilled off
  2. washThe resulting solids are washed with water
  3. dry with materialwith diethyl ether, dried
  4. customrecrystallized from ethanol

Quellen und Nachweise

ORD-Eintrag
ord-f05414f5b307422c99104486583775b9
Quelldatensatz
uspto-grants-1991_07
Patentnummer
US05036086

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