Piperidine → Minoxidil

Beteiligte Stoffe

Reaktionsschritte

After adding 0.49 g (2 mmoles) of 6-acetamido-1-acetoxy-4-chloro-1,2-dihydro-2-iminopyrimidine to a solution containing 10 ml of chloroform and 2 ml of piperidine, the mixture is refluxed for 30 minutes, then evaporated under reduced pressure. The residue is dissolved in the mixture of 10 ml of ethanol and 3 ml of 1N aqueous sodium hydroxide solution. The reaction mixture is left to stand at room temperature for one hour and then again evaporated under reduced pressure. After taking up the residue in 10 ml of water, the crystals are filtered, washed with water and dried to give 0.34 g (80% yield) of the aimed compound which shows no melting point depression when mixed with the product of Example 1.

Herkunft & Nachweise