Hydrochloric Acid → Imidazo[1,2-a]pyridin-8-ol--hydrogen chloride (1/1)
Reaktionsgleichung
C([O:8][C:9]1[C:10]2[N:11]([CH:15]=[CH:16][N:17]=2)[CH:12]=[CH:13][CH:14]=1)C1C=CC=CC=1.[ClH:18]>>[ClH:18].[OH:8][C:9]1[C:10]2[N:11]([CH:15]=[CH:16][N:17]=2)[CH:12]=[CH:13][CH:14]=1Komponenten
3
Versuchsvorschrift
In 80 ml of concentrated hydrochloric acid is dissolved 5 g of 8-benzyloxyimidazo[1,2-a]pyridine, and the solution is stirred at room temperature for 24 hours and then concentrated. After addition of 1-butanol, water is azeotropically removed by distillation, and the residue is crystallized from diethyl ether to give 3.8 g of the above-identified compound.
Aufarbeitung
- concentrationconcentrated
- additionAfter addition of 1-butanol, water
- customis azeotropically removed by distillation
- customthe residue is crystallized from diethyl ether
Quellen und Nachweise
- ORD-Eintrag
- ord-bd6126c91c904e49801df86856223c33
- Quelldatensatz
- uspto-grants-1990_10
- Patentnummer
- US04962100
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