Ethanol → 6-Ethoxyimidazo[1,2-b]pyridazine

HRID 1088242Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1088242
[Na].Cl[C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1.[CH2:12]([OH:14])[CH3:13]>>[CH2:12]([O:14][C:3]1[CH:4]=[CH:5][C:6]2[N:7]([CH:9]=[CH:10][N:11]=2)[N:8]=1)[CH3:13]

Komponenten

4

Edukt 3

HCID 702EthanolHCID 138828Imidazo(1,2-b)pyridazine, 6-chloro-HCID 5360545Sodium

Produkt 1

HCID 200766186-Ethoxyimidazo[1,2-b]pyridazine

Versuchsvorschrift

Sodium metal (0.55 g) is dissolved in 30 ml of ethanol and, to the solution, is added 3 g of 6-chloroimidazo[1,2-b]pyridazine and the mixture is heated under reflux for 3 hours. The solvent is then evaporated off under reduced pressure and the residue is dissolved in water and the mixture is extracted with methylene chloride. The extracts are combined, washed with saturated solution of sodium chloride and dried over MgSO4. The solvent is then evaporated to give 3.3 g of the title compound as colorless crystals.

Aufarbeitung

  1. temperaturethe mixture is heated
  2. temperatureunder reflux for 3 hours
  3. customThe solvent is then evaporated off under reduced pressure
  4. dissolutionthe residue is dissolved in water
  5. extractionthe mixture is extracted with methylene chloride
  6. washwashed with saturated solution of sodium chloride
  7. dry with materialdried over MgSO4
  8. customThe solvent is then evaporated

Quellen und Nachweise

ORD-Eintrag
ord-43663e281df34953b22415d732014315
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04962100

Notizen zur Reaktion

Wird geladen…