Potassium Carbonate → HCID 54541299, Verbindung

HRID 1088448Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1088448
C(=O)([O-])[O-].[K+].[K+].[OH:7][C:8]1[CH:9]=[C:10]([CH:14]=[CH:15][C:16]2[CH:25]=[CH:24][C:23]3[C:18](=[CH:19][CH:20]=[CH:21][CH:22]=3)[N:17]=2)[CH:11]=[CH:12][CH:13]=1.[CH3:26][O:27][C:28](=[O:31])[CH2:29]Br>CC(C)=O>[N:17]1[C:18]2[C:23](=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH:24]=[CH:25][C:16]=1[CH:15]=[CH:14][C:10]1[CH:9]=[C:8]([CH:13]=[CH:12][CH:11]=1)[O:7][CH2:29][C:28]([O:27][CH3:26])=[O:31]

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 60984Methyl bromoacetateHCID 48788413-(2-Quinolin-2-yl-vinyl)-phenol

Produkt 1

HCID 54541299HCID 54541299, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

A suspension of milled potassium carbonate (0.5 g), quinoline from Step 2 (1.1 g), and methylbromoacetate (4.0 ml) in acetone (25 ml) were refluxed overnight. The reaction mixture is poured onto water, extracted with ethyl acetate dried and evaporated. Chromatography of the residue on SiO2 using 30 to 40% ether/hexane afforded the title compound: m.p. 110-112°.

Aufarbeitung

  1. temperaturewere refluxed overnight
  2. additionThe reaction mixture is poured onto water
  3. extractionextracted with ethyl acetate
  4. customdried
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-b7a841ca62e44bfca5a60744eacba619
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04962203

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