Stearyltrimethylammonium chloride → HCID 178442906, Verbindung

HRID 1089379

Reaktionsgleichung

Reaktionsgleichung von HRID 1089379
[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH2:11])=[O:10])([OH:3])=[O:2].[OH-].[Na+].[Cl-].[CH2:23]([N+:41]([CH3:44])([CH3:43])[CH3:42])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40]>CC(C)=O>[CH2:23]([N+:41]([CH3:44])([CH3:42])[CH3:43])[CH2:24][CH2:25][CH2:26][CH2:27][CH2:28][CH2:29][CH2:30][CH2:31][CH2:32][CH2:33][CH2:34][CH2:35][CH2:36][CH2:37][CH2:38][CH2:39][CH3:40].[C:1]([C:4]1[CH:5]=[N:6][N:7]([C:12]2[CH:17]=[C:16]([Cl:18])[CH:15]=[C:14]([Cl:19])[CH:13]=2)[C:8]=1[C:9]([NH-:11])=[O:10])([OH:3])=[O:2]

Komponenten

5

Edukt 3

HCID 8155Stearyltrimethylammonium chlorideHCID 14798Sodium HydroxideHCID 1638961H-Pyrazole-4-carboxylic acid, 5-(aminocarbonyl)-1-(3,5-dichlorophenyl)-

Produkt 1

HCID 178442906HCID 178442906, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

Five g of the compound of Example 2 was slurried in 100 ml of 50% aqueous acetone, 0.67 g of sodium hydroxide was added, and the mixture was warmed and stirred for 15 minutes. Then 10.6 g of octadecyl-trimethylammonium chloride, 50% solution, was added and the mixture was stirred overnight. It was then extracted with 100 ml of ethyl acetate, and the organic layer was washed with brine and dried with sodium sulfate and phase separation paper. The extract was then evaporated under vacuum to obtain 9.95 g of the desired product, m.p. 141°-144°. It was identified by elemental and nuclear magnetic resonance analysis.

Aufarbeitung

  1. temperaturethe mixture was warmed
  2. stirringthe mixture was stirred overnight
  3. extractionIt was then extracted with 100 ml of ethyl acetate
  4. washthe organic layer was washed with brine
  5. dry with materialdried with sodium sulfate and phase separation paper
  6. customThe extract was then evaporated under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-d297d4eaa66b4c96998b41257e12fc20
Quelldatensatz
uspto-grants-1990_10
Patentnummer
US04966623

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