Hydrochloric Acid → Diethyl 2-[(1'-Ethoxy)Ethoxy]Succinate

HRID 1089652

Reaktionsgleichung

Reaktionsgleichung von HRID 1089652
[C:1]([O:11][CH2:12][CH3:13])(=[O:10])[CH:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[OH:3].Cl.[CH:15]([O:17][CH2:18][CH3:19])=[CH2:16]>>[CH2:15]([O:17][CH:18]([O:3][CH:2]([CH2:4][C:5]([O:7][CH2:8][CH3:9])=[O:6])[C:1]([O:11][CH2:12][CH3:13])=[O:10])[CH3:19])[CH3:16]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 8023Ethyl vinyl etherHCID 24197Diethyl malate

Produkt 1

HCID 552076Diethyl 2-[(1'-Ethoxy)Ethoxy]Succinate

Versuchsvorschrift

A mixture of 19 g. diethyl malate and 0.1 g. of 36% hydrochloric acid was added to a 50 ml. round-bottom flask equipped with an addition funnel, static nitrogen head, condensor, heating mantle, thermometer, and magnetic stirrer. Ethyl vinyl ether was then added, dropwise, at 41° to 43° C. over a one-hour period and quenched with 0.4 g. of solid sodium carbonate. Distillation was performed directly on the mixture (short path column):

Aufarbeitung

  1. additionA mixture of 19 g
  2. customround-bottom flask equipped with an addition funnel
  3. temperaturestatic nitrogen head, condensor, heating mantle
  4. waitdropwise, at 41° to 43° C. over a one-hour period
  5. customquenched with 0.4 g
  6. distillationDistillation

Quellen und Nachweise

ORD-Eintrag
ord-4ccd046ae22945088cdef00b8470d9a0
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05079023

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