3-(1H-imidazol-1-yl)propoxyamine → N-(3-(1H-imidazol-1-yl)propoxy)benz(cd)indol-2-amine

HRID 1090237Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090237
[N:1]1([CH2:6][CH2:7][CH2:8][O:9][NH2:10])[CH:5]=[CH:4][N:3]=[CH:2]1.[N:11]1[C:19]2[C:14]3[C:15](=[CH:20][CH:21]=[CH:22][C:13]=3[C:12]=1S)[CH:16]=[CH:17][CH:18]=2>C(O)C>[N:1]1([CH2:6][CH2:7][CH2:8][O:9][NH:10][C:12]2[C:13]3[CH:22]=[CH:21][CH:20]=[C:15]4[C:14]=3[C:19](=[CH:18][CH:17]=[CH:16]4)[N:11]=2)[CH:5]=[CH:4][N:3]=[CH:2]1

Komponenten

4

Edukt 2

HCID 150349943-(1H-imidazol-1-yl)propoxyamineHCID 178527764HCID 178527764, Verbindung

Produkt 1

HCID 15035031N-(3-(1H-imidazol-1-yl)propoxy)benz(cd)indol-2-amineAusbeute 51,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

A mixture consisting of 2.33 grams of 3-(1H-imidazol-1-yl)propoxyamine, 2.84 grams of benz(cd)indol-2-thiol, 4.9 grams of mercuric acetate, and 150 ml of ethanol as stirred and heated under reflux by the conditions of Example 55. The crude product was purified by the chromatographic procedure of Example 46. The resultant orange syrup was recrystallized from ethyl acetate-hexane to give 2.3 grams of the title compound; mp 102° C.-104° C.

Aufarbeitung

  1. temperatureheated
  2. temperatureunder reflux by the conditions of Example 55
  3. customThe crude product was purified by the chromatographic procedure of Example 46
  4. customThe resultant orange syrup was recrystallized from ethyl acetate-hexane

Quellen und Nachweise

ORD-Eintrag
ord-92e1a976caa8420f98fd3c40d235ddb5
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05081131

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