Sodium Hydroxide → 1-Phenyl-1H-pyrazole-5-carboxylic acid

HRID 1090809Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1090809
[C:1]1([N:7]2[C:11]([C:12]([O:14]CC)=[O:13])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH-].[Na+]>C(O)C>[C:1]1([N:7]2[C:11]([C:12]([OH:14])=[O:13])=[CH:10][CH:9]=[N:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 6424675Ethyl 1-phenyl-1H-pyrazole-5-carboxylate

Produkt 1

HCID 2370561-Phenyl-1H-pyrazole-5-carboxylic acidAusbeute 81 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Versuchsvorschrift

4.4 g of ethyl 1-phenylpyrazole-5-carboxylate from Example 1 were stirred for 6 hours at room temperature with 10 ml of 16.5% strength aqueous NaOH and 10 ml of ethanol; the ethanol was removed by distillation, the aqueous phase was extracted twice with 10 ml of toluene, and the pH was adjusted to 3 using concentrated HCl. The precipitate was filtered off under suction, washed with a little water and dried: 3.1 g of product of boiling point 182°-183° C. were obtained.

Aufarbeitung

  1. customthe ethanol was removed by distillation
  2. extractionthe aqueous phase was extracted twice with 10 ml of toluene
  3. filtrationThe precipitate was filtered off under suction
  4. washwashed with a little water
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-f3576e277ae6453ba71ef2be29dddc90
Quelldatensatz
uspto-grants-1992_01
Patentnummer
US05082949

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