Hydrochloric Acid → HCID 19914035, Verbindung

Reaktionsgleichung

Cl.[Na].[C:3]([C:11]1[N:12]([CH2:16][CH2:17][CH:18]2[C:23](=[O:24])[O:22][C:21](C)(C)[O:20][C:19]2=[O:27])[CH:13]=[CH:14][CH:15]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1.[CH3:28]O>>[C:3]([C:11]1[N:12]([CH2:16][CH2:17][CH:18]([C:23]([O:22][CH3:21])=[O:24])[C:19]([O:20][CH3:28])=[O:27])[CH:13]=[CH:14][CH:15]=1)(=[O:10])[C:4]1[CH:9]=[CH:8][CH:7]=[CH:6][CH:5]=1

Komponenten

Edukt 4

HCID 313Hydrochloric Acid

HCID 887Methanol2×

HCID 5360545Sodium

HCID 109147952-Benzoyl-1-[2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]pyrrole

Produkt 1

HCID 19914035HCID 19914035, VerbindungAusbeute 42 %

Versuchsvorschrift

To a 0° C. solution of methanol (10 mL) which had been saturated with gaseous hydrogen chloride was added a solution of the sodium salt of 2-benzoyl-1-[2-(2,2-dimethyl-4,6-dioxo-1,3-dioxan-5-yl)ethyl]pyrrole (1.41 g, 3.9 mmol) in methanol (10 mL). The mixture was stirred for sixteen hours at room temperature and was then concentrated under reduced pressure. The residue was purified by chromato-graphy on silica eluting with hexane/ethyl acetate (70:30) to yield 530 mg (42%) of 2-benzoyl-1-[3,3-di(methoxycarbonyl)propyl]pyrrole.