Trifluoroacetic acid → HCID 11402707, Verbindung
Reaktionsgleichung
C(OC(=O)[NH:7][C:8]([C:11](=[O:16])[N:12]([O:14][CH3:15])[CH3:13])([CH3:10])[CH3:9])(C)(C)C.C(O)(C(F)(F)F)=O>C(O)(C(F)(F)F)=O.C(Cl)Cl>[NH2:7][C:8]([CH3:10])([CH3:9])[C:11]([N:12]([O:14][CH3:15])[CH3:13])=[O:16]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
The Boc-protected Weinreb amide, [1-(methoxy-methyl-carbamoyl)-1-methyl-ethyl]-carbamic acid tert-butyl ester, (1.1 g, 4.47 mmol), was taken up in TFA/CH2Cl2 (1:1, 50 mL) and stirred for 20 min. Removal of the solvent left 2-amino-N-methoxy-2,N-dimethyl-propionamide (1.15 g, 99%, quantitative yield) as its TFA salt. 1H NMR (200 MHz, CD3OD) δ (ppm): 1.63 (s, 6H), 3.25 (s, 3H), 3.78 (s, 3H). MS (ESI, positive ion): m/z 147.3 (M+1)+.
Aufarbeitung
- customRemoval of the solvent
Quellen und Nachweise
- ORD-Eintrag
- ord-6f85c4d974dc4fa5ad7065096d524447
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08129355B2
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