Ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate → 4-(3-Oxomorpholin-4-yl)phenylacetic acid

HRID 1091274Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1091274
[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:13]=[CH:12][C:11]([CH2:14][C:15]([O:17]CC)=[O:16])=[CH:10][CH:9]=1>[OH-].[Na+].C(O)C>[O:1]=[C:2]1[CH2:7][O:6][CH2:5][CH2:4][N:3]1[C:8]1[CH:9]=[CH:10][C:11]([CH2:14][C:15]([OH:17])=[O:16])=[CH:12][CH:13]=1

Komponenten

4

Edukt 1

HCID 58691263Ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate

Produkt 1

HCID 586912414-(3-Oxomorpholin-4-yl)phenylacetic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 702EthanolLösungsmittelHCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

20.2 g (76.8 mmol) of ethyl [4-(3-oxomorpholin-4-yl)phenyl]acetate are dissolved in a solution of 3.37 g of sodium hydroxide in 40 ml of ethanol, and the reaction solution is stirred at room temperature for 18 hours. The reaction mixture is evaporated, and the residue is dissolved in water and acidified to a pH of 3 using 1N hydrochloric acid. The mixture is extracted with ethyl acetate, and the organic phase is dried over sodium sulfate and evaporated, giving 4-(3-oxomorpholin-4-yl)phenylacetic acid as a yellowish solid; ESI 236.

Aufarbeitung

  1. customThe reaction mixture is evaporated
  2. dissolutionthe residue is dissolved in water
  3. extractionThe mixture is extracted with ethyl acetate
  4. dry with materialthe organic phase is dried over sodium sulfate
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-f63c632b42754dddb69e126c488b6b19
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08129373B2

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