HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 1091869Erstellt: 26. Oktober 2026
4-Nitrophenol → 4-Nitrophenyl 6-difluoromethyloxybenzo[4,5]furo[3,2-c]pyridine-9-carboxylate
https://huagongshe.com/reaction/1091869
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | 4-Nitrophenol | HCID 980 | — |
| Edukt | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Edukt | 6-(Difluoromethoxy)[1]benzofuro[3,2-c]pyridine-9-carboxylic acid | HCID 59396155 | — |
| Edukt | 4,4-Dimethyl amino pyridine | HCID 66592228 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 4-Nitrophenyl 6-difluoromethyloxybenzo[4,5]furo[3,2-c]pyridine-9-carboxylate | HCID 59396153 | — |
Reaktionsschritte
A mixture of 6-Difluoromethyloxybenzo[4,5]furo[3,2-c]pyridine-9-carboxylic acid (5.5 g, 0.0197 moles), p-nitro phenol (4.1 g, 0.0295 moles), EDCI (5.7 g, 0.295 moles), 4,4-dimethyl amino pyridine (250 mg, 0.00197 moles) in DMF (603.0 mL) was heated to 70-75° C. for 4-5 hours. The residue obtained after removal of solvent under vacuo was triturated with water (50.0 mL) to give intermediate-18 (6.0 mg) as yellow solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US08129401B2 |
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| Quelldatensatz | uspto-grants-2012_03 |
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| ORD ID | ord-1b4c4db6e728430c9fd79522738316d7 |
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| Quellennotiz | uspto-grants-2012_03 |
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