Trifluoroacetic acid → 2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-yl-pyrimidine Trifluoroacetic Acid Salt

HRID 1091942

Reaktionsgleichung

Reaktionsgleichung von HRID 1091942
C(OC([N:8]1[CH2:13][CH2:12][N:11]([C:14]2[C:19]([CH2:20][O:21][C:22]3[CH:27]=[C:26]([CH:28]([CH3:30])[CH3:29])[CH:25]=[CH:24][C:23]=3[CH3:31])=[C:18]([CH3:32])[N:17]=[C:16]([Cl:33])[N:15]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37]>C(Cl)Cl>[F:34][C:35]([F:40])([F:39])[C:36]([OH:38])=[O:37].[Cl:33][C:16]1[N:17]=[C:18]([CH3:32])[C:19]([CH2:20][O:21][C:22]2[CH:27]=[C:26]([CH:28]([CH3:29])[CH3:30])[CH:25]=[CH:24][C:23]=2[CH3:31])=[C:14]([N:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[N:15]=1

Komponenten

4

Edukt 2

HCID 6422Trifluoroacetic acidHCID 575313954-[2-Chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester

Produkt 1

HCID 866021422-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-4-methyl-6-piperazin-1-yl-pyrimidine Trifluoroacetic Acid Salt

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

To a solution of 4-[2-chloro-5-(5-isopropyl-2-methyl-phenoxymethyl)-6-methyl-pyrimidin-4-yl]-piperazine-1-carboxylic acid tert-butyl ester (500 mg, 1.05 mmol) in DCM (5 mL) is added trifluoroacetic acid (1 mL) with magnetic stirring. Gas evolution is observed and continues for 20 min. The light yellow colored solution is evaporated at reduced pressure, diluted with DCM (20 mL) and evaporated again. Placed under high vacuum (˜0.2 Torr) for 20 min to obtain the title compound as a colorless oil. LC/MS (Method 2), M+H=432.1, Rt=1.46 min.

Aufarbeitung

  1. customThe light yellow colored solution is evaporated at reduced pressure
  2. additiondiluted with DCM (20 mL)
  3. customevaporated again
  4. waitPlaced under high vacuum (˜0.2 Torr) for 20 min

Quellen und Nachweise

ORD-Eintrag
ord-683d19f0f3c14ce28352cb288a1fb24a
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08129395B2

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