Lawesson's reagent → HCID 59355205, Verbindung

HRID 1092644Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1092644
[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([S:9]([C:12]2[CH:25]=[CH:24][C:23]3[N:22]([CH3:26])[C:21]4[C:16](=[CH:17][C:18]([S:27]([N:30]5[CH2:35][CH:34]([CH3:36])[CH2:33][CH:32]([CH3:37])[CH2:31]5)(=[O:29])=[O:28])=[CH:19][CH:20]=4)[C:15](=O)[C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH2:3]1.COC1C=CC(P2(SP(C3C=CC(OC)=CC=3)(=S)S2)=[S:48])=CC=1>C1(C)C=CC=CC=1>[CH3:1][CH:2]1[CH2:7][CH:6]([CH3:8])[CH2:5][N:4]([S:9]([C:12]2[CH:25]=[CH:24][C:23]3[N:22]([CH3:26])[C:21]4[C:16](=[CH:17][C:18]([S:27]([N:30]5[CH2:35][CH:34]([CH3:36])[CH2:33][CH:32]([CH3:37])[CH2:31]5)(=[O:29])=[O:28])=[CH:19][CH:20]=4)[C:15](=[S:48])[C:14]=3[CH:13]=2)(=[O:11])=[O:10])[CH2:3]1

Komponenten

4

Edukt 2

HCID 87949Lawesson's reagentHCID 468511812,7-bis(3,5-dimethylpiperidin-1-ylsulfonyl)-10-methylacridin-9(10H)-one

Produkt 1

HCID 59355205HCID 59355205, VerbindungAusbeute 86,8 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1140TolueneLösungsmittel

Versuchsvorschrift

A mixture of compound 11-4 (560 mg, 1 mmole), anhydrous toluene (10 mL) and Lawesson's reagent (820 mg, 2 mmole) was refluxed for 4 hrs. Toluene was removed by evaporation. To the residue methanol (20 mL) was added, stirred for few minutes at room temperature and the product was collected by filtration and dried to give 500 mg of the title compound. MS 576 (MH+).

Aufarbeitung

  1. temperaturewas refluxed for 4 hrs
  2. customToluene was removed by evaporation
  3. additionTo the residue methanol (20 mL) was added
  4. filtrationthe product was collected by filtration
  5. customdried

Quellen und Nachweise

ORD-Eintrag
ord-a9adf49ea16c4442a0b06d7b067af217
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08129519B2

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