HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
2-Ethylazepane → 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 2-Ethylazepane | HCID 4335932 | — |
| Edukt | 4,6-Dichloro-5-fluoropyrimidine | HCID 11286675 | — |
| Produkt | 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine | HCID 59341131 | 97,2% |
Reaktionsschritte
0.4 g of 4,6-dichloro-5-fluoropyrimidine and 0.61 g of 2-ethylhexahydro-1H-azepine were mixed and left for 1 hour at room temperature. The reaction mixture was subjected to silica gel column chromatography to obtain 0.6 g of 1-(6-chloro-5-fluoropyrimidin-4-yl)-2-ethylhexahydro-1H-azepine.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08129526B2 |
| Quelldatensatz | uspto-grants-2012_03 |
| ORD ID | ord-d5869fe331fb4454bc5b9ab8389f9240 |
| Quellennotiz | uspto-grants-2012_03 |