1-(3-Nitrophenyl)propan-2-one → HCID 85861734, Verbindung

HRID 1092982Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1092982
[N+:1]([C:4]1[CH:5]=[C:6]([CH2:10][C:11](=[O:13])[CH3:12])[CH:7]=[CH:8][CH:9]=1)([O-:3])=[O:2].C1C=C[NH+]=CC=1.[Br:20][Br-]Br>C1COCC1>[Br:20][CH:10]([C:6]1[CH:7]=[CH:8][CH:9]=[C:4]([N+:1]([O-:3])=[O:2])[CH:5]=1)[C:11](=[O:13])[CH3:12]

Komponenten

3

Edukt 1

HCID 125079341-(3-Nitrophenyl)propan-2-one

Produkt 1

HCID 85861734HCID 85861734, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A stirred solution of 3-nitrophenylacetone (2.5 g, 14.0 mmol) in dry THF (50 ml) at room temperature is treated with polymer supported pyridine hydrobromide perbromide (7.0 g, 14.0 mmol) and left to stir overnight. The reaction mixture is then filtered and the solvent removed in vacuo. The residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane to give the titled compound.

Aufarbeitung

  1. waitleft
  2. filtrationThe reaction mixture is then filtered
  3. customthe solvent removed in vacuo
  4. customThe residue is purified by chromatography on silica eluting with 1:4 ethyl acetate-hexane

Quellen und Nachweise

ORD-Eintrag
ord-f67e3f88fc314871a62188dcd41599ea
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08129541B2

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