Benzyl Alcohol → 4-(Benzyloxy)-3-(trifluoromethyl)benzoic acid

To a solution of potassium t-butoxide (27.5 g) in N,N-dimethylformamide (120 ml) was added dropwise a solution of benzyl alcohol (15.9 ml) in N,N-dimethylformamide (60 ml) over min. The mixture was stirred for 30 min, and a solution of 4-fluoro-3-trifluoromethylbenzoic acid (20.0 g) in N,N-dimethylformamide (90 ml) was added under ice-cooling. The mixture was stirred at room temperature for 1 hr, and further at 50° C. for 1 hr. The reaction mixture was added to ice water, and acidified with 1M hydrochloric acid (300 ml). The precipitated solid was collected by filtration, and washed with water and then hexane to give the object product (28.2 g) as a white powder.

1. temperaturecooling
2. stirringThe mixture was stirred at room temperature for 1 hr
3. waitfurther at 50° C. for 1 hr
4. filtrationThe precipitated solid was collected by filtration
5. washwashed with water

ORD-Eintrag

ord-d17a7f01b4804136b4d732fa17f78b88

Quelldatensatz

uspto-grants-2012_03

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US08129361B2