4-Benzyloxy-3-ethyl-5-methyl-benzoic acid hydrazide → 2-Ethyl-4-[5-(5-isobutyl-4-methyl-thiophen-2-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenol
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[C:4]([C:11]([OH:13])=O)[S:5][C:6]=1[CH:7]=[C:8]([CH3:10])[CH3:9].C([O:21][C:22]1[C:31]([CH3:32])=[CH:30][C:25]([C:26]([NH:28][NH2:29])=O)=[CH:24][C:23]=1[CH2:33][CH3:34])C1C=CC=CC=1>>[CH2:33]([C:23]1[CH:24]=[C:25]([C:26]2[O:13][C:11]([C:4]3[S:5][C:6]([CH2:7][CH:8]([CH3:9])[CH3:10])=[C:2]([CH3:1])[CH:3]=3)=[N:29][N:28]=2)[CH:30]=[C:31]([CH3:32])[C:22]=1[OH:21])[CH3:34]Komponenten
3
Versuchsvorschrift
2-Ethyl-4-[5-(5-isobutyl-4-methyl-thiophen-2-yl)-[1,3,4]oxadiazol-2-yl]-6-methyl-phenol is prepared from 4-methyl-5-(2-methyl-propenyl)-thiophene-2-carboxylic acid and 4-benzyloxy-3-ethyl-5-methyl-benzoic acid hydrazide in analogy to Example 29; LC-MS: tR=1.13 min, [M+1]+=357.49.
Quellen und Nachweise
- ORD-Eintrag
- ord-a75976e3675e48e89d2b88c902811dd8