HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl iodide → 4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl iodide | HCID 6328 | — |
| Edukt | beta,beta-Dimethyl-1H-indole-3-ethanamine | HCID 27303 | — |
| Edukt | tert-Butyl 3-(cyanomethyl)-1H-indole-1-carboxylate | HCID 15378323 | — |
| Produkt | 4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester | HCID 66640193 | — |
Reaktionsschritte
4,4-Dimethyl-2,3,4,9-tetrahydro-1H-beta-carboline-1-carboxylic acid ethyl ester was prepared in a manner similar to that described in Example 66A by replacing tryptamine-HCl with 2-(1H-indol-3-yl)-2-methylpropylamine, which was synthesized using 2 equivalents of iodomethane during alkylation of (1-tert-butoxycarbonylindol-3-yl)acetonitrile as described in Example 32B; MS (ESI): 273 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08133992B2 |
| Quelldatensatz | uspto-grants-2012_03 |
| ORD ID | ord-6c58ebbd58174390a0fb835cfc526589 |
| Quellennotiz | uspto-grants-2012_03 |