Potassium Carbonate → HCID 57743223, Verbindung
Reaktionsgleichung
[Cl:1][C:2]1[CH:9]=[C:6]([CH:7]=[O:8])[C:5]([OH:10])=[CH:4][CH:3]=1.[CH3:11][C:12]1([CH3:25])[CH2:17][CH:16](OS(C)(=O)=O)[CH2:15][C:14]([CH3:24])([CH3:23])[O:13]1.C([O-])([O-])=O.[K+].[K+]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([O:10][CH:16]2[CH2:15][C:14]([CH3:24])([CH3:23])[O:13][C:12]([CH3:25])([CH3:11])[CH2:17]2)=[C:6]([CH:9]=1)[CH:7]=[O:8]Komponenten
5
Edukt 3
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
In a manner similar to the method described in example 4a, 5-chlorosalicylaldehyde (4.6 g, 30 mmol) (Aldrich) reacted with methanesulfonic acid 2,2,6,6-tetramethyl-tetrahydro-pyran-4-yl ester (8 g, 34 mmol) and K2CO3 in N,N-dimethylformamide to give 5-chloro-2-(2,2,6,6-tetramethyl-tetrahydro-pyran-4-yloxy)-benzaldehyde as a off white solid (Yield 0.94 g, 10%).