HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Acetyl chloride → 1-[5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Acetyl chloride | HCID 6367 | — |
| Edukt | Trimethylsilane | HCID 70435 | — |
| Edukt | Lithium Hexamethyldisilazide | HCID 2733832 | — |
| Edukt | 5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)benzaldehyde | HCID 57743182 | — |
| Lösungsmittel | Triethylamine | HCID 8471 | — |
| Produkt | 1-[5-Fluoro-2-(tetrahydro-thiopyran-4-yloxy)-phenyl]-3-trimethylsilyoxy-2-aza-1,3-butadiene | HCID 66641230 | — |
Reaktionsschritte
In a manner similar to the method described in Example 112b, 5-fluoro-2-(tetrahydro-thiopyran-4-yloxy)-benzaldehyde was treated with LHMDS, acetyl chloride, triethylamine and trimethyl silane to give the desired compound, which was directly used for the next step.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08134001B2 |
| Quelldatensatz | uspto-grants-2012_03 |
| ORD ID | ord-3ae3bfe9706b46dcb457e63e0b627a3d |
| Quellennotiz | uspto-grants-2012_03 |