3-(2-Bromoethyl)indole → Indole, 3-(2-(isoindolin-2-yl)ethyl)-

HRID 1095530Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1095530
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1.[CH:13]1[NH:14][CH:15]=[C:16]2[C:21]=1[CH:20]=[CH:19][CH:18]=[CH:17]2>O1CCOCC1>[CH2:13]1[C:21]2[C:16](=[CH:17][CH:18]=[CH:19][CH:20]=2)[CH2:15][N:14]1[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[NH:6][CH:5]=1

Komponenten

4

Edukt 2

HCID 769243-(2-Bromoethyl)indoleHCID 3013853Isoindole

Produkt 1

HCID 39465Indole, 3-(2-(isoindolin-2-yl)ethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

A solution of 3-(2-bromo-ethyl)-1H-indole (4.48 g, 20 mmol) and isoindole (4.76 g, 40 mmol) in abs. dioxane (50 ml) was stirred at 80° C. for 6 h. The solvent was then removed i. vac., CHCl3 (100 ml) was added to the residue and the mixture was washed twice with water. The organic phase was dried over Na2SO4 and concentrated i. vac. and the residue which remained was purified by flash chromatography with CHCl3/MeOH (20:1).

Aufarbeitung

  1. customThe solvent was then removed i
  2. addition, CHCl3 (100 ml) was added to the residue
  3. washthe mixture was washed twice with water
  4. dry with materialThe organic phase was dried over Na2SO4
  5. concentrationconcentrated i
  6. customand the residue which remained was purified by flash chromatography with CHCl3/MeOH (20:1)

Quellen und Nachweise

ORD-Eintrag
ord-bc4bcb7578264a7e9adcb73371d5f13f
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138187B2

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