Potassium Carbonate → (4-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxymethyl}-phenyl)-acetic acid methyl ester

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	Potassium Carbonate	HCID 11430	—
Edukt	Methyl 2-(4-(bromomethyl)phenyl)acetate	HCID 11770640	—
Edukt	3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol	HCID 57421264	—
Produkt	(4-{3-Chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenoxymethyl}-phenyl)-acetic acid methyl ester	HCID 46940905	—

Reaktionsschritte

In analogy to Example 1, step 7, 3-chloro-4-[2-(2-chloro-pyridin-4-yl)-3,3,3-trifluoro-2-hydroxy-1-methyl-propyl]-phenol (Example 19, Step 5) was reacted with methyl 4-(bromomethyl)phenylacetate and potassium carbonate to give the title compound as a colorless waxy solid. MS (m/e)=528.1 [M+H+].

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US08138189B2
Quelldatensatz	uspto-grants-2012_03
ORD ID	ord-ec438dd71cd04a85867a8bedb3c1f7c8
Quellennotiz	uspto-grants-2012_03