Ethyl 4-(chlorosulfonyl)benzoate → HCID 86645951, Verbindung

HRID 1095915

Reaktionsgleichung

Reaktionsgleichung von HRID 1095915
[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=[O:12])=[CH:7][CH:6]=1)[CH3:2].[NH2:16][C:17]1[CH:22]=[CH:21][C:20]([CH:23]([CH3:37])[C:24]([C:30]2[CH:35]=[CH:34][N:33]=[C:32]([Cl:36])[CH:31]=2)([OH:29])[C:25]([F:28])([F:27])[F:26])=[C:19]([Cl:38])[CH:18]=1>N1C=CC=CC=1>[CH2:1]([O:3][C:4](=[O:15])[C:5]1[CH:10]=[CH:9][C:8]([S:11](=[O:13])(=[O:12])[NH:16][C:17]2[CH:22]=[CH:21][C:20]([CH:23]([CH3:37])[C:24]([C:30]3[CH:35]=[CH:34][N:33]=[C:32]([Cl:36])[CH:31]=3)([OH:29])[C:25]([F:26])([F:27])[F:28])=[C:19]([Cl:38])[CH:18]=2)=[CH:7][CH:6]=1)[CH3:2]

Komponenten

4

Edukt 2

HCID 3667622Ethyl 4-(chlorosulfonyl)benzoateHCID 86629109HCID 86629109, Verbindung

Produkt 1

HCID 86645951HCID 86645951, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 1049PyridineLösungsmittel

Versuchsvorschrift

4-Chlorosulfonyl-benzoic acid ethyl ester (CAS Reg. No. 10486-51-8, 15 mg) was added to a solution of 3-(4-amino-2-chloro-phenyl)-2-(2-chloro-pyridin-4-yl)-1,1,1-trifluoro-butan-2-ol (Example 68 step 4, 20 mg) in pyridine (0.8 ml). The solution was stirred for 30 min at room temperature. The mixture was purified by prep. HPLC (C18-column, solvent gradient 20-98% CH3CN in 0.1% HCOOH[aq]) to give the title compound (18 mg) as a light yellow foam. MS (m/e)=577.1 [M+H+].

Aufarbeitung

  1. customThe mixture was purified by prep

Quellen und Nachweise

ORD-Eintrag
ord-e04d08561a9344fcbc94adbffc17fee3
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138189B2

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