1-Iodo-3-(trifluoromethoxy)benzene → 4-(3-Piperidin-1-yl-propyl)-1-(3-trifluoromethoxy-phenyl)-[1,4]diazepan-5-one
Reaktionsgleichung
[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:16](=[O:17])[CH2:15][CH2:14][NH:13][CH2:12][CH2:11]2)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.I[C:19]1[CH:24]=[CH:23][CH:22]=[C:21]([O:25][C:26]([F:29])([F:28])[F:27])[CH:20]=1>>[N:1]1([CH2:7][CH2:8][CH2:9][N:10]2[C:16](=[O:17])[CH2:15][CH2:14][N:13]([C:23]3[CH:24]=[CH:19][CH:20]=[C:21]([O:25][C:26]([F:27])([F:28])[F:29])[CH:22]=3)[CH2:12][CH2:11]2)[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1Komponenten
3
Versuchsvorschrift
The title compound was prepared from 4-(3-piperidin-1-yl-propyl)-[1,4]diazepan-5-one (Example 33B) and 1-iodo-3-trifluoromethoxy-benzene in analogy to example 33. MS: 400.2 (MH+).
Quellen und Nachweise
- ORD-Eintrag
- ord-b79e35eedc2642f497451a397e547a2a
- Quelldatensatz
- uspto-grants-2012_03