HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Ethyl ketone → tert-butyl N-[4-[[[(6S)-4-oxo-3-(pentan-3-ylamino)-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Ethyl ketone | HCID 7288 | — |
| Edukt | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Edukt | tert-butyl N-[4-[[[(6S)-3-amino-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate | HCID 145857226 | — |
| Edukt | tert-butyl N-[4-[[[(6S)-3-(benzylamino)-4-oxo-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate | HCID 145857234 | — |
| Produkt | tert-butyl N-[4-[[[(6S)-4-oxo-3-(pentan-3-ylamino)-7,8-dihydro-6H-pyrrolo[1,2-a]pyrimidine-6-carbonyl]amino]methyl]benzenecarboximidoyl]carbamate | HCID 145857228 | 24% |
Reaktionsschritte
Following a procedure similar to that for the preparation of intermediate 1k, intermediate 1j (100 mg, 0.234 mmol), 3-pentanone (33.8 mg, 0.469 mmol) and NaBH(OAc)3 (139.1 mg, 0.657 mmol) yielded 27.8 mg (24%) of intermediate 11a. MS (ESI) 497.1 (M+H+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07094783B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-426cc82d056b47df9fa707ca8f83e735 |
| Quellennotiz | uspto-grants-2006_08 |