Sulfuric Acid → HCID 178438224, Verbindung
Reaktionsgleichung
[CH2:1]([C:3]1([CH:8]([F:13])[C:9]([NH:11][OH:12])=[O:10])OCCO1)[CH3:2].OS(O)(=O)=O>>[CH2:1]([C:3]1[O:12][N:11]=[C:9]([OH:10])[C:8]=1[F:13])[CH3:2]Komponenten
3
Versuchsvorschrift
A sol. of 2-(2-ethyl-[1,3]dioxolan-2-yl)-2-fluoro-N-hydroxyacetamide (502 mg, 2.60 mmol) in cone. H2SO4 (1.2 mL) was stirred for 2 h at rt, then for 2 h at 50° C. The mixture was poured onto ice, and this mixture was extracted with EtOAc. The combined org. extracts were dried over MgSO4, filtered, and the solvents were removed under reduced pressure. Drying the residue under high vacuum yielded the title compound (280 mg, 82%). LC-MS: tR=0.66, ES+: not visible.
Aufarbeitung
- additionThe mixture was poured onto ice
- extractionthis mixture was extracted with EtOAc
- dry with materialextracts were dried over MgSO4
- filtrationfiltered
- customthe solvents were removed under reduced pressure
- customDrying the residue under high vacuum
Quellen und Nachweise
- ORD-Eintrag
- ord-34d778ebad034d348b7d33d7373bd868
- Quelldatensatz
- uspto-grants-2012_03
- Patentnummer
- US08138340B2
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