3-Chloro-2,6-difluorophenol → 7-{4-[3-(3-Chloro-2,6-difluorophenoxy)propyl]thiazol-2-yl}-6-[cyclopropyl-(2,3-dichlorobenzyl)-carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

HRID 1096862

Reaktionsgleichung

Reaktionsgleichung von HRID 1096862
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:10]([CH2:11][C:12]([C:39]3[S:40][CH:41]=[C:42]([CH2:44][CH2:45][CH2:46][OH:47])[N:43]=3)=[C:13]2[C:24](=[O:38])[N:25]([CH:35]2[CH2:37][CH2:36]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=2[Cl:34])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:48][C:49]1[C:50]([F:57])=[C:51](O)[C:52]([F:55])=[CH:53][CH:54]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:10]([CH2:11][C:12]([C:39]3[S:40][CH:41]=[C:42]([CH2:44][CH2:45][CH2:46][O:47][C:51]4[C:52]([F:55])=[CH:53][CH:54]=[C:49]([Cl:48])[C:50]=4[F:57])[N:43]=3)=[C:13]2[C:24](=[O:38])[N:25]([CH:35]2[CH2:36][CH2:37]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([Cl:33])[C:28]=2[Cl:34])[CH2:9]1)=[O:7])([CH3:4])([CH3:2])[CH3:3]

Komponenten

3

Edukt 2

HCID 27735643-Chloro-2,6-difluorophenolHCID 685707746-[Cyclopropyl-(2,3-dichlorobenzyl)carbamoyl]-7-[4-(3-hydroxypropyl)thiazol-2-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

Produkt 1

HCID 685709677-{4-[3-(3-Chloro-2,6-difluorophenoxy)propyl]thiazol-2-yl}-6-[cyclopropyl-(2,3-dichlorobenzyl)-carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

Versuchsvorschrift

This compound is prepared from compound E4 and 3-chloro-2,6-difluorophenol, according to the above-described procedure A.

Quellen und Nachweise

ORD-Eintrag
ord-8bd0f24c9805413eb64f4fb69ef550e0
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138340B2

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