3-Chloro-2,6-difluorophenol → 7-{2-[2-(3-Chloro-2,6-difluorophenoxy)ethoxy]thiazol-5-yl}-6-[cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

HRID 1096870

Reaktionsgleichung

Reaktionsgleichung von HRID 1096870
[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:23])([CH3:22])[CH3:21])=[O:18])[CH:10]([CH2:11][C:12]([C:40]3[S:44][C:43]([O:45][CH2:46][CH2:47][OH:48])=[N:42][CH:41]=3)=[C:13]2[C:24](=[O:39])[N:25]([CH:36]2[CH2:38][CH2:37]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[C:28]=2[CH3:35])[CH2:9]1)=[O:7])([CH3:4])([CH3:3])[CH3:2].[Cl:49][C:50]1[C:51]([F:58])=[C:52](O)[C:53]([F:56])=[CH:54][CH:55]=1>>[C:1]([O:5][C:6]([N:8]1[CH2:15][CH:14]2[N:16]([C:17]([O:19][C:20]([CH3:21])([CH3:23])[CH3:22])=[O:18])[CH:10]([CH2:11][C:12]([C:40]3[S:44][C:43]([O:45][CH2:46][CH2:47][O:48][C:52]4[C:53]([F:56])=[CH:54][CH:55]=[C:50]([Cl:49])[C:51]=4[F:58])=[N:42][CH:41]=3)=[C:13]2[C:24](=[O:39])[N:25]([CH:36]2[CH2:37][CH2:38]2)[CH2:26][C:27]2[CH:32]=[CH:31][CH:30]=[C:29]([O:33][CH3:34])[C:28]=2[CH3:35])[CH2:9]1)=[O:7])([CH3:2])([CH3:3])[CH3:4]

Komponenten

3

Edukt 2

HCID 27735643-Chloro-2,6-difluorophenolHCID 685707976-[Cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-7-[2-(2-hydroxyethoxy)thiazol-5-yl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

Produkt 1

HCID 690853017-{2-[2-(3-Chloro-2,6-difluorophenoxy)ethoxy]thiazol-5-yl}-6-[cyclopropyl-(3-methoxy-2-methylbenzyl)carbamoyl]-3,9-diazabicyclo[3.3.1]non-6-ene-3,9-dicarboxylic acid di-tert-butyl ester

Versuchsvorschrift

This compound is prepared from compound E9 and 3-chloro-2,6-difluorophenol, according to the above-described procedure A. LC-MS: tR=1.23 min, ES+: 831.38.

Quellen und Nachweise

ORD-Eintrag
ord-bfe9995b0c3746f5b3545fdc64dafde7
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138340B2

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