Hydrochloric Acid → 6-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

HRID 1096930Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1096930
C[O:2][C:3]1[N:8]=[CH:7][C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])=[CH:5][CH:4]=1.[ClH:32]>>[ClH:32].[O:2]=[C:3]1[NH:8][CH:7]=[C:6]([C:9]2[CH:10]=[C:11]3[C:28](=[CH:29][CH:30]=2)[O:27][C:14]2([CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)[CH2:13][C:12]3=[O:31])[CH:5]=[CH:4]1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 57930941Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4'-piperidine]-1'-carboxylate

Produkt 1

HCID 667818066-(6-Oxo-1,6-dihydropyridin-3-yl)spiro[chroman-2,4'-piperidin]-4-one hydrochloride

Versuchsvorschrift

Tert-Butyl 6-[6-(methoxy)pyridin-3-yl]-4-oxo-spiro[chroman-2,4′-piperidine]-1′-carboxylate (550 mg) was suspended in conc. HCl aq. (10 ml) and stirred at 100 deg. for 20 h. After removal of the solvent, the resulted solid was washed with MeOH and Et2O to obtain the intended compound as a colorless solid.

Aufarbeitung

  1. customAfter removal of the solvent
  2. washthe resulted solid was washed with MeOH and Et2O

Quellen und Nachweise

ORD-Eintrag
ord-7afb32bd2310406d95e54586a7e82680
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138197B2

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