Hydrochloric Acid → 3,5-Diethoxy-4-isoxazol-4-yl-benzoic acid

HRID 1096991Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1096991
[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:19][CH2:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][O:17][CH:18]=1)[C:7]([O:9]C)=[O:8])[CH3:2].Cl>CO.C1COCC1.[OH-].[Na+]>[CH2:1]([O:3][C:4]1[CH:5]=[C:6]([CH:11]=[C:12]([O:19][CH2:20][CH3:21])[C:13]=1[C:14]1[CH:15]=[N:16][O:17][CH:18]=1)[C:7]([OH:9])=[O:8])[CH3:2]

Komponenten

5

Edukt 2

HCID 313Hydrochloric AcidHCID 57931014Methyl 3,5-diethoxy-4-(isoxazol-4-yl)benzoate

Produkt 1

HCID 579309183,5-Diethoxy-4-isoxazol-4-yl-benzoic acid

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 14798Sodium HydroxideLösungsmittelHCID 21899815MeOH tetrahydrofuranLösungsmittel

Versuchsvorschrift

Methyl 3,5-diethoxy-4-(isoxazol-4-yl)benzoate (91 mg) was dissolved in a mixed solvent of methanol/THF (8 mL, 3/5), aqueous 1 M NaOH solution (1.2 mL) was added to it, and stirred at room temperature for 5 hours. Aqueous 1 M HCl solution (1.2 mL) was added to it, and the solvent was concentrated under reduced pressure. The formed solid was taken out through filtration, washed with water, and dried under reduced pressure to obtain the title compound as a pale yellow solid.

Aufarbeitung

  1. additionwas added to it
  2. concentrationthe solvent was concentrated under reduced pressure
  3. filtrationThe formed solid was taken out through filtration
  4. washwashed with water
  5. customdried under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-553a18b38cc445e484a6466a8808f0a3
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08138197B2

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