1-(Bromomethyl)-2,3-difluoro-benzene → HCID 178508256, Verbindung

HRID 1097330

Reaktionsgleichung

Reaktionsgleichung von HRID 1097330
CC(C)([O-])C.[K+].[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[NH:14][C:13](=[S:17])[NH:12][C:11]=2[N:18]=1.[F:19][C:20]1[C:27]([F:28])=[CH:26][CH:25]=[CH:24][C:21]=1[CH2:22]Br>CS(C)=O>[NH2:7][C:8]1[S:9][C:10]2[C:15](=[O:16])[N:14]=[C:13]([S:17][CH2:22][C:21]3[CH:24]=[CH:25][CH:26]=[C:27]([F:28])[C:20]=3[F:19])[NH:12][C:11]=2[N:18]=1

Komponenten

5

Edukt 3

HCID 5179841-(Bromomethyl)-2,3-difluoro-benzeneHCID 114583092-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-oneHCID 23665647Potassium tert-butoxide

Produkt 1

HCID 178508256HCID 178508256, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 679Dimethyl SulfoxideLösungsmittel

Versuchsvorschrift

Potassium t-butoxide solution (0.45 ml of 1M solution in tetrahydrofuran) was added to a stirred solution of 2-amino-5,6-dihydro-5-thioxo-thiazolo[4,5-d]pyrimidin-7(4H)-one (0.09 g) [Cited: Indian J. Chem., Sect. B (1989), 28B(11), 964-5.] and 2,3-difluorobenzyl bromide in dimethyl sulphoxide (2 ml). After stirring for 3 days, the reaction mixture was poured onto water to give and the subtitle compound, isolated by filtration.

Aufarbeitung

  1. additionthe reaction mixture was poured onto water
  2. customto give

Quellen und Nachweise

ORD-Eintrag
ord-41c3cb54a6b1406fafc1c847ad29de30
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143261B2

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