Hydrochloric Acid → 2-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

HRID 1097367Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1097367
[OH-:1].[K+].Br[C:4]1[S:5][C:6]2[C:11]([NH:12][C@H:13]([CH3:16])[CH2:14][OH:15])=[N:10][C:9]([S:17][CH2:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[F:25])=[N:8][C:7]=2[N:26]=1.Cl.[CH3:28]O>>[F:25][C:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[CH2:18][S:17][C:9]1[N:10]=[C:11]([NH:12][C@H:13]([CH3:16])[CH2:14][OH:15])[C:6]2[S:5][C:4]([O:1][CH3:28])=[N:26][C:7]=2[N:8]=1

Komponenten

5

Edukt 4

HCID 313Hydrochloric AcidHCID 887MethanolHCID 14797Potassium HydroxideHCID 235198302-[[2-bromo-5-[[(2-fluorophenyl)methyl]thio]thiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Produkt 1

HCID 235198412-[[5-[[(2-fluorophenyl)methyl]thio]-2-methoxythiazolo[4,5-d]pyrimidin-7-yl]amino]-(2R)-1-propanol

Versuchsvorschrift

Potassium hydroxide (27 mg) was added to a solution of the product of example 32 step d) (0.1 g) in MeOH (10 ml). The mixture was stirred for 24 h before neutralising to pH 7 with 2M HCl solution. The volatiles were removed in vacuo and the product used directly in the following step.

Aufarbeitung

  1. customThe volatiles were removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-5190058fe4494eeb962ad03fb95a17ea
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143261B2

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