HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Allyl iodide → 6-allyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid tert-butyl Ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Allyl iodide | HCID 11166 | — |
| Edukt | tert-Butyl (S)-3-{[(benzyloxy)carbonyl]amino}-4-oxo-4,6,7,8-tetrahydropyrrolo[1,2-a]pyrimidine-6-carboxylate | HCID 54224046 | — |
| Edukt | 3-benzyloxycarbonylamino-6-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid tert-butyl Ester | HCID 69600879 | — |
| Produkt | 6-allyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid tert-butyl Ester | HCID 69600950 | 55% |
Reaktionsschritte
According to the procedure for the preparation of intermediate 19a, alkylation of intermediate 1g (250 mg, 0.649 mmol) with allyl iodide afforded 153 mg (55%) of intermediate 20a. MS (ESI) 426.4 (M+H+), 448.4 (M+Na+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07094783B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-7977f68c4da0489ebc38176d5555ba59 |
| Quellennotiz | uspto-grants-2006_08 |