6-benzyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic Acid → benzyl N-[6-benzyl-6-[[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]phenyl]methylcarbamoyl]-4-oxo-7,8-dihydropyrrolo[1,2-a]pyrimidin-3-yl]carbamate

HRID 10979

Reaktionsgleichung

Reaktionsgleichung von HRID 10979
[CH2:1]([C:8]1([C:29]([OH:31])=O)[N:12]2[C:13](=[O:28])[C:14]([NH:17][C:18]([O:20][CH2:21][C:22]3[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=3)=[O:19])=[CH:15][N:16]=[C:11]2[CH2:10][CH2:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:32]([O:36][C:37](=[O:49])[NH:38][C:39]([C:41]1[CH:46]=[CH:45][C:44]([CH2:47][NH2:48])=[CH:43][CH:42]=1)=[NH:40])([CH3:35])([CH3:34])[CH3:33]>>[CH2:21]([O:20][C:18](=[O:19])[NH:17][C:14]1[C:13](=[O:28])[N:12]2[C:8]([CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)([C:29](=[O:31])[NH:48][CH2:47][C:44]3[CH:45]=[CH:46][C:41]([C:39]([NH:38][C:37]([O:36][C:32]([CH3:35])([CH3:34])[CH3:33])=[O:49])=[NH:40])=[CH:42][CH:43]=3)[CH2:9][CH2:10][C:11]2=[N:16][CH:15]=1)[C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1

Komponenten

3

Edukt 2

HCID 219796936-benzyl-3-benzyloxycarbonylamino-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidine-6-carboxylic AcidHCID 145832046tert-butyl N-[4-(aminomethyl)benzenecarboximidoyl]carbamate

Produkt 1

HCID 145857196benzyl N-[6-benzyl-6-[[4-[N-[(2-methylpropan-2-yl)oxycarbonyl]carbamimidoyl]phenyl]methylcarbamoyl]-4-oxo-7,8-dihydropyrrolo[1,2-a]pyrimidin-3-yl]carbamate

Versuchsvorschrift

According to the procedure for the preparation of intermediate 19c, intermediate 21b (50 mg, 0.119 mmol) was coupled with [(4-aminomethyl-phenyl)-imino-methyl]-carbamic acid tert-butyl ester to afford 77 mg (quantitative) of intermediate 21c.

Quellen und Nachweise

ORD-Eintrag
ord-012f6202a1704b24b330c77a049c3fbc
Quelldatensatz
uspto-grants-2006_08
Patentnummer
US07094783B2

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