5-Methylpyrazin-2-amine → 2-hydroxy-N-(5-methylpyrazin-2-yl)hexanamide
Reaktionsgleichung
[Si]([O:8][CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([O:12]CC)=O)(C(C)(C)C)(C)C.[NH2:19][C:20]1[CH:25]=[N:24][C:23]([CH3:26])=[CH:22][N:21]=1>>[OH:8][CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([NH:19][C:20]1[CH:25]=[N:24][C:23]([CH3:26])=[CH:22][N:21]=1)=[O:12]Komponenten
3
Versuchsvorschrift
The title compound was prepared in a manner similar to that described for Intermediate A3, starting from ethyl 2-{[tert-butyl(dimethyl)silyl]oxy}hexanoate and 2-amino-5-methylpyrazine, 1H NMR (300 MHz, CDCl3) δ 9.46 (s, 1H), 8.98 (br s, 1H), 8.12 (s, 1H), 4.32 (m, 1H), 2.98 (d, 1H), 2.54 (s, 3H), 1.96 (m, 1H), 1.78 (m, 1H), 1.44 (m, 4H), 0.93 (t, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-41b38e0a73b740f09e1cc67e76f8e31b
- Quelldatensatz
- uspto-grants-2012_03