2-Amino-4-methylthiazole → 2-hydroxy-N-(4-methyl-1,3-thiazol-2-yl)hexanamide
Reaktionsgleichung
[Si]([O:8][CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([O:12]CC)=O)(C(C)(C)C)(C)C.[NH2:19][C:20]1[S:21][CH:22]=[C:23]([CH3:25])[N:24]=1>>[OH:8][CH:9]([CH2:15][CH2:16][CH2:17][CH3:18])[C:10]([NH:19][C:20]1[S:21][CH:22]=[C:23]([CH3:25])[N:24]=1)=[O:12]Komponenten
3
Versuchsvorschrift
The title compound was prepared in a manner similar to that described for Intermediate A3, starting from ethyl 2-{[tert-butyl(dimethyl)silyl]oxy}hexanoate and 2-amino-4-methylthiazole, 1H NMR (300 MHz, CDCl3) δ 10.30 (br s, 1H), 6.54 (s, 1H), 5.12 (br s, 1H), 4.41 (m, 1H), 2.35 (s, 3H), 2.00 (m, 1H), 1.76 (m, 1H), 1.48 (m, 2H), 1.39 (m, 2H), 0.92 (t, 3H).
Quellen und Nachweise
- ORD-Eintrag
- ord-656e76fe4ede46aaa5722addce6da2dc
- Quelldatensatz
- uspto-grants-2012_03