Hydrochloric Acid → 2-(4-Aminophenoxy)acetic acid hydrochloride

HRID 1098698

Reaktionsgleichung

Reaktionsgleichung von HRID 1098698
C([O:3][C:4](=[O:17])[CH2:5][O:6][C:7]1[CH:12]=[CH:11][C:10]([NH:13]C(=O)C)=[CH:9][CH:8]=1)C.[ClH:18]>>[ClH:18].[NH2:13][C:10]1[CH:9]=[CH:8][C:7]([O:6][CH2:5][C:4]([OH:17])=[O:3])=[CH:12][CH:11]=1

Komponenten

3

Edukt 2

HCID 313Hydrochloric AcidHCID 309738Ethyl 2-(4-acetamidophenoxy)acetate

Produkt 1

HCID 668114882-(4-Aminophenoxy)acetic acid hydrochlorideAusbeute 77,6 %

Reaktionsbedingungen

Temperatur
10 °C

Versuchsvorschrift

(4-Acetylamino-phenoxy)-acetic acid ethyl ester 1 (375 grams, 1.582 mmol), in concentrated Hydrochloric acid (9.36 liters) was refluxed for 12 Hours. Excess concentrated Hydrochloric acid was distilled off in vacuum and filtered hot. The mixture was cooled to 10° C., filtered and dried to give pure 2 (250 g, 77.6%) as a wheat colored powder.

Aufarbeitung

  1. distillationExcess concentrated Hydrochloric acid was distilled off in vacuum
  2. filtrationfiltered hot
  3. filtrationfiltered
  4. customdried

Quellen und Nachweise

ORD-Eintrag
ord-1e4f733c5ee44033a8ef14b4a58c4c49
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143325B2

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