N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide → 1-(3-Pentafluoroethyl-phenyl)-ethylamine

HRID 1098750

Reaktionsgleichung

Reaktionsgleichung von HRID 1098750
[F:1][C:2]([F:19])([C:7]1[CH:8]=[C:9]([C:13]([NH:15]C(=O)C)=[CH2:14])[CH:10]=[CH:11][CH:12]=1)[C:3]([F:6])([F:5])[F:4]>CO>[F:1][C:2]([F:19])([C:7]1[CH:8]=[C:9]([CH:13]([NH2:15])[CH3:14])[CH:10]=[CH:11][CH:12]=1)[C:3]([F:4])([F:6])[F:5]

Komponenten

3

Edukt 1

HCID 59506293N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide

Produkt 1

HCID 723100481-(3-Pentafluoroethyl-phenyl)-ethylamine

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

To a solution of N-[1-(3-Pentafluoroethyl-phenyl)-vinyl]-acetamide (110 mg, 0.39 mmol) in methanol (10 ml) was added (+)-1,2-bis((2S,5S)-2,5-diethylphospholano)benzene(cyclooctadiene)rhodium (I) trifluoromethanesulfonate (0.3 mg). The reaction mixture was hydrogenated with H2 at 5 bar and evaporated. The residue was dissolved in ethanol and hydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days. Purification by preparative HPLC and lyophilization of the relevant fractions gave the desired product.

Aufarbeitung

  1. customevaporated
  2. dissolutionThe residue was dissolved in ethanol
  3. temperaturehydrochloric acid (6 M, 0.7 ml) and the solution was refluxed for 2 days
  4. customPurification by preparative HPLC and lyophilization of the relevant fractions

Quellen und Nachweise

ORD-Eintrag
ord-68bd9dcb77a841f693a53736ac5ad86d
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143242B2

Verknüpfte Notizen

Wird geladen…