Cesium carbonate → 5-Iodo-1-(4-pyridyl)-1H-indazole

HRID 1098898Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1098898
C(=O)([O-])[O-].[Cs+].[Cs+].F[C:8]1[CH:15]=[CH:14][C:13]([I:16])=[CH:12][C:9]=1[CH:10]=O.Cl.Cl.[N:19]1[CH:24]=[CH:23][C:22]([NH:25][NH2:26])=[CH:21][CH:20]=1>CN1CCCC1=O>[I:16][C:13]1[CH:12]=[C:9]2[C:8](=[CH:15][CH:14]=1)[N:25]([C:22]1[CH:23]=[CH:24][N:19]=[CH:20][CH:21]=1)[N:26]=[CH:10]2

Komponenten

5

Edukt 3

HCID 10796Cesium carbonateHCID 162170582-Fluoro-5-iodobenzaldehydeHCID 230141794-Hydrazinylpyridine dihydrochloride

Produkt 1

HCID 668127495-Iodo-1-(4-pyridyl)-1H-indazoleAusbeute 92,3 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 13387N-methyl-2-pyrrolidoneLösungsmittel

Versuchsvorschrift

Cesiumcarbonate (26.84 g, 82.38 mmol) is added to a suspension of 2-fluoro-5-iodobenzaldehyde (6.87 g, 27.46 mmol) and 4-pyridylhydrazine dihydrochloride (5 g, 27.46 mmol) in 136 mL N-methylpyrrolidon. The reaction mixture is stirred overnight at r.t. After checking that the hydrazone has been formed (1H-NMR) the reaction mixture is heated for 4 h at 160° C. The reaction mixture is allowed to cool down and the darkbrown suspension is poured on 1000 mL ice water. After vigorously stirring at r.t. for 45 min, the precipitated product is sucked off via a glass microfibre filter, washed with water and dried at the evaporator at 45° C. The title compound is obtained with a yield of 92.3% (8.14 g).

Aufarbeitung

  1. customhas been formed (1H-NMR) the reaction mixture
  2. temperatureis heated for 4 h at 160° C
  3. temperatureto cool down
  4. stirringAfter vigorously stirring at r.t. for 45 min
  5. filtrationfilter
  6. washwashed with water
  7. customdried at the evaporator at 45° C

Quellen und Nachweise

ORD-Eintrag
ord-c4c41ac7693f4f69a31f21d8b6301e68
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143290B2

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