HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Hydrochloric Acid → Hydrochloric Acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Hydrochloric Acid | HCID 313 | — |
| Edukt | t-Butyl (1R,2R)-1-(2,3-dihydrobenzofuran-6-yl)-1-hydroxypropan-2-ylcarbamate | HCID 59339796 | — |
| Lösungsmittel | Ethyl Acetate | HCID 8857 | — |
| Produkt | Hydrochloric Acid | HCID 313 | 98% |
| Produkt | (1R,2R)-2-amino-1-(2,3-dihydrobenzofuran-6-yl)propan-1-ol | HCID 66812942 | — |
Reaktionsschritte
t-Butyl (1R,2R)-1-(2,3-dihydrobenzofuran-6-yl)-1-hydroxypropan-2-ylcarbamate (1.58 g, 5.39 mmol) was stirred in a solution of HCl in EtOAc (1M, 20 ml) at 60° C. for 2 h. After cooling the solid precipitate was filtered and dried to afford the subtitle compound as hydrochloride (1.22 g, 98%).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US08143290B2 |
| Quelldatensatz | uspto-grants-2012_03 |
| ORD ID | ord-1909e949f81d4a8db81a81b187bb24c4 |
| Quellennotiz | uspto-grants-2012_03 |