2-Fluoroethanol → HCID 58019811, Verbindung

HRID 1099106Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1099106
CC(C)([O-])C.[K+].[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]=[C:13]([NH2:23])[N:14]=[C:15](N3C=NC=N3)[C:16]=2[N:17]=1.[F:24][CH2:25][CH2:26][OH:27]>C(Cl)Cl>[Cl:7][C:8]1[CH:9]=[CH:10][C:11]2[N:12]=[C:13]([NH2:23])[N:14]=[C:15]([O:27][CH2:26][CH2:25][F:24])[C:16]=2[N:17]=1

Komponenten

5

Edukt 3

HCID 97372-FluoroethanolHCID 23665647Potassium tert-butoxideHCID 576983146-Chloro-4-(1H-1,2,4-triazol-1-yl)pyrido[3,2-d]pyrimidin-2-amine

Produkt 1

HCID 58019811HCID 58019811, VerbindungAusbeute 44 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

Potassium tert-butoxide (2.8 mL; 1M in THF) was added to a suspension of 6-chloro-4-[1,2,4]triazol-1-yl-pyrido[3,2-d]pyrimidin-2-ylamine (0.7 g) and 2-fluoroethanol (0.83 mL) in DCM (100 mL). After stirring at room temperature for 10 minutes, the mixture was diluted with DCM (100 mL) and washed with brine. The organic layer was dried over Na2SO4 and concentrated to afford 6-chloro-4-(2-fluoro-ethoxy)-pyrido[3,2-d]pyrimidin-2-ylamine as a yellow solid (0.3 g, yield: 44%) was characterized by its mass spectrum as follows: MS (m/z) 243.1 [M+H]+.

Aufarbeitung

  1. washwashed with brine
  2. dry with materialThe organic layer was dried over Na2SO4
  3. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-ab240405354d4b41b3b09d9dcbd22a83
Quelldatensatz
uspto-grants-2012_03
Patentnummer
US08143394B2

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