3-(Trifluoromethyl)phenethylic alcohol → N-(4-{2-[3-(Trifluoromethyl)phenyl]ethoxy}benzoyl)glycine
Reaktionsgleichung
C([O:5][C:6](=[O:18])[CH2:7][NH:8][C:9](=[O:17])[C:10]1[CH:15]=[CH:14][C:13]([OH:16])=[CH:12][CH:11]=1)(C)(C)C.[F:19][C:20]([F:31])([F:30])[C:21]1[CH:22]=[C:23]([CH2:27][CH2:28]O)[CH:24]=[CH:25][CH:26]=1>>[F:19][C:20]([F:30])([F:31])[C:21]1[CH:22]=[C:23]([CH2:27][CH2:28][O:16][C:13]2[CH:12]=[CH:11][C:10]([C:9]([NH:8][CH2:7][C:6]([OH:5])=[O:18])=[O:17])=[CH:15][CH:14]=2)[CH:24]=[CH:25][CH:26]=1Komponenten
3
Versuchsvorschrift
The same reaction as in Example 1 (1b) was conducted using N-(4-hydroxybenzoyl)glycine tert-butyl ester (502 mg, 2.00 mmol) prepared in Example 1 (1a) and 2-[3-(trifluoromethyl)phenyl]ethanol (330 μL, 2.20 mmol) to give 368 mg of the title compound (white powder, yield: 80%).
Quellen und Nachweise
- ORD-Eintrag
- ord-10e9a8939b6f4e04848b719daa5532aa
- Quelldatensatz
- uspto-grants-2012_03