HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
(6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-8-methyl-4-oxo-6-phenylcarbamoyl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid tert-butyl ester → (6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | (6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-8-methyl-4-oxo-6-phenylcarbamoyl-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic acid tert-butyl ester | HCID 69600880 | — |
| Edukt | (6S,8R)-allyl-[8-azido-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-3-yl]-carbamic Acid Benzyl Ester | HCID 86590670 | — |
| Produkt | (6R,8S)-[3-(allyl-benzyloxycarbonyl-amino)-6-(tert-butoxycarbonyl-phenyl-aminocarbonyl)-8-methyl-4-oxo-4,6,7,8-tetrahydro-pyrrolo[1,2-a]pyrimidin-8-yl]-acetic Acid tert-butyl Ester | HCID 69600731 | 82% |
Reaktionsschritte
Following a procedure similar to that for the preparation of intermediate 18e, intermediate 38a (435.9 mg, 0.76 mmol), was protected to give 418.9 mg (82%) of intermediate 38b. MS (ESI) 673.4 (M+H+), 695.3 (M+Na+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07094783B2 |
| Quelldatensatz | uspto-grants-2006_08 |
| ORD ID | ord-a42c8550554944cb81be6dab778dd8cf |
| Quellennotiz | uspto-grants-2006_08 |