2-Fluoromethyl-2-phthalimido-5-iodopentanenitrile → 2-Fluoromethyl-2,5-diphthalimidopentanenitrile

HRID 1105618Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1105618
[F:1][CH2:2][C:3]([N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])([CH2:6][CH2:7][CH2:8]I)[C:4]#[N:5].[C:21]1(=[O:31])[NH:25][C:24](=[O:26])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]12.[K]>CN(C)C=O>[F:1][CH2:2][C:3]([N:10]1[C:14](=[O:15])[C:13]2=[CH:16][CH:17]=[CH:18][CH:19]=[C:12]2[C:11]1=[O:20])([CH2:6][CH2:7][CH2:8][N:25]1[C:24](=[O:26])[C:23]2=[CH:27][CH:28]=[CH:29][CH:30]=[C:22]2[C:21]1=[O:31])[C:4]#[N:5]

Komponenten

4

Edukt 2

HCID 147716572-Fluoromethyl-2-phthalimido-5-iodopentanenitrileHCID 24194345Phthalimide potassium salt

Produkt 1

HCID 199663332-Fluoromethyl-2,5-diphthalimidopentanenitrile

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

2-Fluoromethyl-2-phthalimido-5-iodo-valeronitrile (1.20 g, 3.11 mmol) and potassium phthalimide (0.75 g, 4 mmol) are heated in dimethylformamide (25 mL) to 80° C. for 2 hours. After standing overnight at room temperature, the DMF is removed by vacuum distillation and the residue is dissolved in chloroform and washed with 1 N KOH and water. After drying (Na2SO4), evaporation gives 2-fluoromethyl-2,5-diphthalimidovalerontrile as a solid.

Aufarbeitung

  1. customthe DMF is removed by vacuum distillation
  2. dissolutionthe residue is dissolved in chloroform
  3. washwashed with 1 N KOH and water
  4. customAfter drying
  5. custom(Na2SO4), evaporation
  6. customgives 2-fluoromethyl-2,5-diphthalimidovalerontrile as a solid

Quellen und Nachweise

ORD-Eintrag
ord-e1ea909a21ad4a778c5d9fffbb0be767
Quelldatensatz
uspto-grants-1982_01
Patentnummer
US04309442

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