Acetyl isothiocyanate → HCID 13023177, Verbindung

HRID 1105833Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1105833
[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH2:22])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2].[C:24]([N:27]=[C:28]=[S:29])(=[O:26])[CH3:25]>CC(C)=O>[C:1]([NH:5][C:6](=[S:23])[NH:7][C:8]1[CH:9]=[C:10]([CH:19]=[CH:20][C:21]=1[NH:22][C:28]([NH:27][C:24](=[O:26])[CH3:25])=[S:29])[C:11]([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)=[O:12])([O:3][CH3:4])=[O:2]

Komponenten

4

Edukt 2

HCID 128851Acetyl isothiocyanateHCID 30369724-Amino-3-(3'-methoxycarbonyl-2'-thioureido)benzophenone

Produkt 1

HCID 13023177HCID 13023177, VerbindungAusbeute 54 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 180AcetoneLösungsmittel

Versuchsvorschrift

To a suspension of 3-(3-carbomethoxythioureido)-4-aminobenzophenone (1.2 g.; 0.0036 mole) in acetone (15 ml.) is added acetyl isothiocyanate (0.37 g.; 0.0036 mole). The reaction mixture is heated to reflux and then allowed to stand at room temperature for 18 hours. The product is collected by filtration, washed successively to afford 0.85 g. (54% yield) of 3-(3-carbomethoxythioureido)-4-(3-acetylthioureido)benzophenone, m.p. 210° C., dec.

Aufarbeitung

  1. temperatureThe reaction mixture is heated
  2. temperatureto reflux
  3. filtrationThe product is collected by filtration
  4. washwashed successively
  5. customto afford 0.85 g

Quellen und Nachweise

ORD-Eintrag
ord-e84afdf185344eae9b18d65a1ee6ca8c
Quelldatensatz
uspto-grants-1982_01
Patentnummer
US04310537

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